ASSOCIAÇÃO ENTRE OBESIDADE GRAVE E DEPRESSÃO: REVISÃO INTEGRATIVA DA LITERATURA
Abstract
Severe obesity and depression are highly prevalent, bidirectionally interconnected chronic conditions, in which obesity increases the risk of depressive symptoms and depression promotes weight gain, creating a complex cycle. This integrative review analyzes ten studies published between 2020 and 2025, encompassing clinical trials, observational studies, and prospective studies investigating nutritional, behavioral, and integrated interventions. The results show that strategies such as restrictive diets, intermittent fasting, prebiotic supplementation, and combined programs of nutritional re-education, physical activity, and psychological support promote weight loss and, in some cases, improvement in depressive symptoms, although the effects on mood and quality of life remain heterogeneous. Thus, an association between obesity and depression must be understood as multifactorial, requiring integrated, individualized, and sustainable therapeutic approaches to improve clinical outcomes and reduce the impact of these conditions on public health.
References
DAKANALIS, Antonios et al. The association of emotional eating with overweight/obesity, depression, anxiety/stress, and dietary patterns: a review of the current clinical evidence. Nutrients Basel, v. 15, n. 5, p. 1173, 2023. Disponível em: https://doi.org/10.3390/nu15051173. Acesso em: 15 set. 2025.
KATAOKA, Josefin et al. Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome. Scientific Reports London, v. 14, n. 13495, 2024. Disponível em: https://doi.org/10.1038/s41598-024-63166-w. Acesso em: 15 set. 2025.
KAUFMANN, Lisa-Katrin et al. Additive effects of depression and obesity on neural correlates of inhibitory control. Journal of Affective DisordersAmsterdam, v. 362, p. 174-185, 2024. Disponível em: https://doi.org/10.1016/j.jad.2024.06.093. Acesso em: 15 set. 2025.
LIN, Shuhao et al. Effect of time-restricted eating versus daily calorie restriction on mood and quality of life in adults with obesity. Nutrients Basel, v. 15, n. 20, p. 4313, 2023. Disponível em: https://doi.org/10.3390/nu15204313. Acesso em: 15 set. 2025.
LV, Nan et al. Sex moderates diet quality differences in integrated collaborative care for comorbid obesity and depression: post-hoc analysis of the RAINBOW RCT. The Journal of Nutrition, Health and Aging Paris, v. 29, 2025. Disponível em: https://doi.org/10.1016/j.jnha.2024.100426. Acesso em: 15 set. 2025.
ROSAS, Lisa G. et al. Understanding mechanisms of integrated behavioral therapy for co-occurring obesity and depression in primary care: a mediation analysis in the RAINBOW trial. Translational Behavioral Medicine Oxford, v. 11, n. 2, p. 381-392, 2021. Disponível em: https://doi.org/10.1093/tbm/ibaa024. Acesso em: 15 set. 2025.
VAGHEF-MEHRABANI, Elnaz et al. Effects of inulin supplementation on inflammatory biomarkers and clinical symptoms of women with obesity and depression on a calorie-restricted diet: a randomised controlled clinical trial. British Journal of Nutrition Cambridge, v. 129, n. 11, p. 1897-1907, 2022. Disponível em: https://doi.org/10.1017/S000711452200232X. Acesso em: 15 set. 2025.
