CHALLENGES IN DIAGNOSING CREUTZFELDT-JAKOB SYNDROME

Abstract

CREUTZFELDT-JAKOB (CJD) IS A RAPIDLY PROGRESSIVE, RARE, TRANSMISSIBLE, UNIVERSALLY FATAL NEURODEGENERATIVE CONDITION THAT BELONGS TO A FAMILY OF PRION DISEASES OR SPONGIFORM ENCEPHALOPATHIES. BECAUSE IT IS SUCH A LETHAL DISEASE, THE DIAGNOSIS SHOULD BE MADE IMMEDIATELY, AS ITS TARDINESS CAN CAUSE HIGH SEVERITY SEQUELS AND EVOLVE TO DEATHS DUE TO THE LACK OF EXISTING TREATMENT. HOWEVER, THERE IS SOME DIFFICULTY IN IDENTIFYING THIS PATHOLOGY, DUE TO ITS RARITY AND ITS SIMILARITY WITH OTHER NEURODEGENERATIVE DISEASES. THE METHODOLOGY USED FOR THE ELABORATION OF THE EXPANDED ABSTRACT WAS THE SEARCH FOR ARTICLES IN THE PUBMED, COCHRANE AND LILACS SITES, FROM 2016 TO 2018. FROM THIS, WE DISCUSSED THE EFFICACY OF EXAMS SUCH AS ELECTROCEPHALOGRAM, MAGNETIC NUCLEAR RESONANCE, LIQUID BIOPSY CEFALORRAQUIDIANO AND THE EXPERIMENTAL EXAMINATION OF THE USE OF THE MALFORMED CYCLIC AMPLIFICATION OF PROTEIN. THUS, WE WERE ABLE TO ADDRESS DIFFERENTIAL FACTORS FOR DETERMINING CJD.