SYSTEMIC LEVELS OF BIOCHEMICAL COMPONENTS AND INFLAMMATORY MARKERS IN PATIENTS WITH SEVERE OBESITY: A LITERATURE REVIEW
Keywords:
Severe obesity, Bariatric surgery, Biochemical markersAbstract
Introduction: Obesity is currently one of the most serious public health problems. Its prevalence has been growing sharply in recent decades, even in developing countries, turning it into a global epidemic. Severe obesity is a complex condition that manifests itself through significant changes in the systemic levels of these inflammatory markers and biochemical components, often leading to the recommendation of bariatric surgery. Objective: To verify the systemic levels of biochemical components and inflammatory markers in different studies with the severely obese population. Methodology: Five original articles were extracted from the PubMed, Google Scholar, and Scielo databases, published between 2018 and 2024. The Health Sciences Descriptors (DeCS) used for the search were: “severe obesity,” “bariatric surgery,” and “biochemical markers,” with the Boolean operator “AND.” The inclusion criteria were publications in any language, original studies, and free access. Results: in obese individuals, there is an increase in glucose levels, blood lipids, and inflammatory markers, such as CRP and IL-6, in addition to an increase in oxidative stress, which can contribute to metabolic and cardiovascular comorbidities, requiring therapeutic interventions that modulate these markers. Conclusion: The studies analyzed demonstrated that obesity significantly impacts several biochemical markers, exacerbating both glycemic and lipid conditions and promoting a chronic inflammatory state.
References
NASCIMENTO, G. M.; et al. Prevalence of body phenotypes and their associations with biomarkers of glycemic, lipid, and inflammatory profiles: a population-based study. Cadernos de Saúde Pública, 5th ed., v.40, p. 1-13, 2024.
CAVALCANTI, T. V. O.; et al. Acute effects of strength training at different intensities on inflammatory markers in women with severe obesity. J Phys Educ, v.33, e. 3358, 2022.
GIULIANI, N.R.; et al. Prospective study of the inflammatory response in patients undergoing abdominoplasty after bariatric surgery. Revista Brasileira de Cirurgia Plástica. v.2, ed 36, p.129-133, 2021.
CHIELLE, E. O.; GENS F.; ROSSI E. R. Oxidative, inflammatory, and cardiometabolic biomarkers of clinical relevance in patients with metabolic syndrome. J Bras Patol Med Lab, v.4, ed.54, p.213-219, 2018.
MENEZES, C. A.; et al. Genetic polymorphisms and plasma concentrations of leptin and adiponectin associated with obesity in children and adolescents. Rev Paul pediatr, v.40, e2021030, 2022.
RODRIGUEZ-AYALA E.; et al. Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study. Adipocyte, v.1, ed. 9, p.153-169, 2020.
FRÜHBECK G. The adipose tissue as a source of vasoactive factors. Curr Med Chem Cardiovasc Hematol Agents, v. 3, ed.2, p.197-208, 2004.
ELAGIZI A.; et al. An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases. Prog Cardiovasc Dis, v. 2, ed. 61, p142-150, 2018.
JAACKS L. M.; et al. The obesity transition: stages of the global epidemic. Lancet Diabetes Endocrinol, v. 3, ed.7, p. 231-240, 2019.
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