LIVER FIBROSIS DEGREE ASSESSED BY HEPATIC ELASTOGRAPHY IN SEVERELY OBESE PATIENTS INDICATED FOR BARIATRIC SURGERY: A LITERATURE REVIEW
Keywords:
Non-alcoholic fatty liver disease, hepatic fibrosis, bariatric surgery, elastography, obesityAbstract
Introduction: Obesity is a global health problem that has increased significantly in recent years. Bariatric surgery emerges as a treatment alternative for individuals with morbid obesity. Alongside obesity, the prevalence of non-alcoholic fatty liver disease (NAFLD) has also risen, predisposing these individuals to cirrhosis and hepatocellular carcinoma. Currently, liver biopsy remains the gold standard for diagnosis; however, it is an invasive procedure with potential complications. Therefore, new non-invasive tests have been proposed to identify such changes, such as hepatic elastography, which allows the detection of liver fibrosis without invasive procedures. Objective: To identify the degree of hepatic fibrosis in severely obese patients indicated for bariatric surgery using hepatic elastography.
Methodology: Seven clinical trials were extracted from PubMed, published between 2019 and 2024. Health Science Descriptors (DeCS) used were: “Bariatric Surgery,” “Elastography,” and “Obesity.” Inclusion criteria were original studies published in English. Results: Elastography proved effective in detecting fibrosis, showing no significant differences when compared with liver biopsy. Only one study failed to show diagnostic accuracy in patients with higher BMI values. Conclusion: Elastography can be used to identify liver fibrosis in this population; however, further studies are required to reinforce these findings.
References
Organização Mundial da Saúde. Obesity. Disponível em: https://www.who.int/health-topics/obesity/#tab=tab_1. Acesso em: 15 set. 2024.
GUO, X.; YIN, X.; LIU, Z.; WANG, J. Non-Alcoholic Fatty Liver Disease (NAFLD) Pathogenesis and Natural Products for Prevention and Treatment. International Journal Of Molecular Sciences, [S.L.], v. 23, n. 24, p. 15489, 7 dez. 2022.
YANG, X.; LI, Q.; LIU, W.; ZONG, C.; WEI, L.; SHI, Y.; HAN, Z. Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment. Cellular & Molecular Immunology, [S.L.], v. 20, n. 6, p. 583-599, 24 fev. 2023.
ARTERBURN, D. E.; TELEM, D. A.; KUSHNER, R. F.; COURCOULAS, A. P. Benefits and Risks of Bariatric Surgery in Adults. Jama, [S.L.], v. 324, n. 9, p. 879, 1 set. 2020.
RINALDI, L.; GIORGIONE, C.; MORMONE, A.; ESPOSITO, F.; RINALDI, M.; BERRETTA, M.; MARFELLA, R.; ROMANO, C. Non-Invasive Measurement of Hepatic Fibrosis by Transient Elastography: a narrative review. Viruses, [S.L.], v. 15, n. 8, p. 1730, 13 ago. 2023.
CHIMORIYA, R.; PIYA, M. K.; SIMMONS, D.; AHLENSTIEL, G.; HO, V. The Use of Two-Dimensional Shear Wave Elastography in People with Obesity for the Assessment of Liver Fibrosis in Non-Alcoholic Fatty Liver Disease. Journal Of Clinical Medicine, [S.L.], v. 10, n. 1, p. 95, 29 dez. 2020.
SILVA, R. G.; MIRANDA, M. L. Q.; BRANT, P. E. A. C.; SCHULZ, P. O.; NASCIMENTO, M. F. A.; SCHMILLEVITCH, J.; VIEIRA, A.; FREITAS, W. R.; SZUTAN, L. A. Acoustic radiation force impulse elastography and liver fibrosis risk scores in severe obesity. Archives Of Endocrinology And Metabolism, [S.L.], v. 65, n. 5, p. 730-738, 11 nov. 2021.
LIMA, R. R.; GARCIA, J. H. P.; STUDART, M. S.; PINHEIRO, F. S.; PINTO, J. O. G.; SALES, L. A.; SOARES, L. M.; SANTOS, P. A. ACCURACY OF ELASTOGRAPHY IN THE ASSESSMENT OF REDUCTION IN LIVER STEATOSIS AND FIBROSIS IN THE EARLY POSTOPERATIVE PERIOD AFTER BARIATRIC SURGERY. Abcd. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), [S.L.], v. 35, p. 1-4, ago. 2022.
AGARWAL, L.; AGGARWAL, S.; SHALIMAR; YADAV, R.; DATTAGUPTA, S.; GARG, H.; AGARWAL, S. Bariatric Surgery in Nonalcoholic Fatty Liver Disease (NAFLD): impact assessment using paired liver biopsy and fibroscan. Obesity Surgery, [S.L.], v. 31, n. 2, p. 617-626, 17 set. 2020.
TAN, H. C.; SHUMBAYAWONDA, E.; BEYER, C.; CHENG, L. T.-E.; LOW, A.; LIM, C. H.; ENG, A.; CHAN, W. H.; LEE, P. C.; TAY, M. F.; KIN, S.; CHANG, J. P. E.; BEE, Y. M.; GOH, G. B. B. Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease. International Journal Of Biomedical Imaging, [S.L.], v. 2023, p. 1-8, 19 jul. 2023.
LIU, S. Y.; WONG, V. W.; WONG, S. K.; WONG, G. L.; LAI, C. M.; LAM, C. C.; SHU, S. S.; CHAN, H. L.; NG, E. K. A prospective 5-year study on the use of transient elastography to monitor the improvement of non-alcoholic fatty liver disease following bariatric surgery. Scientific Reports, [S.L.], v. 11, n. 1, p. 1-11, 8 mar. 2021.
COCCIA, F.; TESTA, M.; GUARISCO, G.; BONCI, E.; CRISTOFANO, C.; SILECCHIA, G.; LEONETTI, F.; GASTALDELLI, A.; CAPOCCIA, D. Noninvasive assessment of hepatic steatosis and fibrosis in patients with severe obesity. Endocrine, [S.L.], v. 67, n. 3, p. 569-578, 19 dez. 2019.
KAUL, A.; SINGLA, V.; BAKSI, A.; AGGARWAL, S.; BHAMBRI, A.; SHALIMAR; YADAV, R. Safety and Efficacy of Bariatric Surgery in Advanced Liver Fibrosis. Obesity Surgery, [S.L.], v. 30, n. 11, p. 4359-4365, 3 jul. 2020.
Downloads
Published
Issue
Section
License
These Proceedings offer free and immediate access to their content, based on the principle that making scientific knowledge freely available to the public fosters the global democratization of knowledge.
Upon publication in the Proceedings, authors retain copyright and publication rights to their articles without restriction.
The Proceedings of the International Congress on Research, Teaching, and Extension (CIPEEX) of the Evangelical University of Goiás (UniEVANGÉLICA) adhere to the terms of the Creative Commons Attribution-NonCommercial 4.0 International license.