ESTUDO DO FATOR DE CRESCIMENTO NEURAL (NGF) EM PACIENTES COM REAÇO HANS�NICA TIPO 1 E 2
Palavras-chave:
hanseníase, fator de crescimento neural, reações hansênicasResumo
NO PERMEAR DO CURSO DA HANSEN�ASE, AS REA��ES HANS�NICAS SÃO EPISÓDIOS AGUDOS IMUNO-INFLAMATÓRIOS QUE DEFINEM A MAIOR CAUSA DE INCAPACIDADES F�SICAS E DEFORMIDADES PERMANENTES, EM DECORR�NCIA DO DANO NEURAL QUE PODE SE DESENVOLVER RAPIDAMENTE DURANTE OS EPISÓDIOS REACIONAIS. NEUROTROFINAS SÃO UMA FAMÍLIA DE PROTE�NAS GRANDE IMPORT�NCIA NA NEUROPLASTICIDADE E, EM ESPECIAL, O FATOR DE CRESCIMENTO NEURONAL (NERVE GROWTH FACTOR - NGF) REGULA PROCESSOS DE REGENERA��O E DIFERENCIA��O NEURAL, BEM COMO A PERCEP��O DE DOR. OBSERVA-SE ALTERADA EXPRESSÃO DE NGF EM DIVERSAS DOEN�AS INFLAMATÓRIAS E AUTOIMUNES, COMO NA ARTRITE REUMATOIDE, L�PUS ERITEMATOSO SIST�MICO E TIREOIDITE. NESSE CONTEXTO, SUGERE-SE UMA PARTICIPA��O DO NGF NA PATOG�NESE DA HANSEN�ASE E SUA CORRELA��O COM DIFERENTES FORMAS CL�NICAS DA DOEN�A E FEN�MENOS DE REGENERA��O OU INJ�RIA NEURAL DURANTE A INFEC��O.
Referências
AARÃO, T. L.S et al. Nerve growth Factor and Pathogenesis of leprosy: Review and Uptade. Frontiers and Immunology, v.9, p. 1-8, 2018.
ANGST, D. B. M. et al. Cytokine levels in neural pain in leprosy. Frontiers in Immunology, v. 11, p. 23, 2020.
BAHIA EL IDRISSI, N. et al. In Situ complement activation and T-cell immunity in leprosy spectrum: An immunohistological study on leprosy lesional skin. PLoS One, v. 12, n. 5, p. e0177815, 2017.
BARCELOS, R. M. F. M. et al. Leprosy patients quality of life: a scoping review. Revista da Escola de Enfermagem da USP, v. 55, 2021.
BELACHEW, W. A.; NAAFS, B. Position statement: LEPROSY: Diagnosis, treatment and followâ€up. Journal of the European Academy of Dermatology and Venereology, v. 33, n. 7, p. 1205-1213, 2019.
BRACCI-LAUDIERO, L.; DE STEFANO, M. E. NGF in early embryogenesis, differentiation, and pathology in the nervous and immune systems. Neurotoxin Modeling of Brain Disorders—Life-long Outcomes in Behavioral Teratology, p. 125-152, 2015.
BRASIL. MINISTÉRIO DA SAÚDE. Guia prático sobre a hansenÃase. Ministério da Saúde, Secretaria e Vigilância em Saúde, Departamento de Vigilância das Doenças TransmissÃveis. – BrasÃlia: Ministério da Saúde, 2017.
CLEMENTS, M. P. et al. The wound microenvironment reprograms Schwann cells to invasive mesenchymal-like cells to drive peripheral nerve regeneration. Neuron, v. 96, n. 1, p. 98-114. e7, 2017.
COGEN, A. L. et al. Biologics in leprosy: a systematic review and case report. The American journal of tropical medicine and hygiene, v. 102, n. 5, p. 1131, 2020.
DE SOUSA, J. R.; SOTTO, M. N.; QUARESMA, J. A. S. Leprosy as a complex infection: Breakdown of the Th1 and Th2 immune paradigm in the immunopathogenesis of the disease. Frontiers in Immunology, [s. l.], v. 8, n. NOV, p. 18–21, 2017.
FISCHER, M. Leprosy – an overview of clinical features, diagnosis, and treatment. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, v. 15, n. 8, p. 801-827, 2017.
FONSECA, A. B. L. et al. The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy. Infectious diseases of poverty, v. 6, n. 1, p. 1-8, 2017.
IOANNOU, M. S.; FAHNESTOCK, M. ProNGF, but not NGF, switches from neurotrophic to apoptotic activity in response to reductions in TrkA receptor levels. International journal of molecular sciences, v. 18, n. 3, p. 599, 2017.
MAYMONE, M. B. C. et al. Leprosy: Treatment and management of complications. Journal of the American Academy of Dermatology, v. 83, n. 1, p. 17-30, 2020.
MIN, Q.; PARKINSON, D. B.; DUN, X. Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge. Glia, v. 69, n. 2, p. 235-254, 2021.
RIDLEY, D. S.; JOPLING, W. H. Classification of leprosy according to immunity. A five-group system. International Journal Leprosy and Other Mycobacterium Disease, [s. l.], v. 34, n. 3, p. 255–273, 1966.
SERRANO-COLL, H. et al. Mycobacterium leprae-induced nerve damage: direct and indirect mechanisms. Pathogens and disease, v. 76, n. 6, p. fty062, 2018.
WORLD HEALTH ORGANIZATION (WHO). Global leprosy update, 2020: impact of COVID-19 on global leprosy control. Weekly Epidemiological Record, v. 96, n. 36, p. 421-444, 2021.
