COLORRECTAL CANCER AND ITS INFLUENCING FACTORS: AN INTEGRATIVE LITERATURE REVIEW
Palavras-chave:
dieta, neoplasias colorretais, câncer colorretal, genéticaResumo
COLORECTAL NEOPLASIA IS A DEGENERATION OF THE INTESTINAL EPITHELIUM THAT CAN BE ACCOMPANIED BY POLYPS AND, ACCORDING TO THE NATIONAL CANCER INSTITUTE (2022), COVERS TUMORS THAT START IN THE COLON, RECTUM AND ANUS. IT IS THE THIRD MOST COMMON TYPE OF CANCER IN THE AMERICAS, AFFECTING ALMOST 2 MILLION PEOPLE IN 2018 AND THE SECOND TYPE OF CANCER THAT KILLS THE MOST IN THE AMERICAN CONTINENT, AND THEREFORE IT IS NECESSARY THAT THE POPULATION IS AWARE OF ITS RISK FACTORS, SO THAT THE DIAGNOSIS IS NOT LATE AND THUS INCREASES THE EFFECTIVENESS OF THE TREATMENT. THIS STUDY IS AN INTEGRATIVE LITERATURE REVIEW WHOSE AIM WAS TO SEEK EVIDENCE THAT CORRELATES THE DEVELOPMENT OF CRC WITH GENETICS AND LIFESTYLE. TO CARRY OUT THIS STUDY, A SEARCH WAS CARRIED OUT IN THE ELECTRONIC DATABASES LATIN AMERICAN AND CARIBBEAN LITERATURE IN HEALTH SCIENCES (LILACS), SCIENTIFIC ELECTRONIC LIBRARY ONLINE (SCIELO) AND PUBLISHER MEDLINE (PUBMED).THE DESCRIPTORS USED WERE �€ŒC�NCER COLORETAL�€, �€ŒGEN�TICA�€, �€ŒDIETA�€ AND �€ŒOBESIDADE�€, WITH THE BOOLEAN AND. THEY WERE INCLUDED ORIGINAL ARTICLES PUBLISHED BETWEEN 2017 AND 2024 WRITTEN IN SPANISH, ENGLISH AND PORTUGUESE. IN THE END, 17 ARTICLES WERE SELECTED, WHICH WERE DIVIDED INTO THREE CATEGORIES OF INFLUENCE: GENETICS, FOOD AND ENVIRONMENT. THE RESULTS POINTED TO A GREAT INFLUENCE OF THE THREE CATEGORIES FOUND. IN THIS WAY, IT WAS PROVED THAT CERTAIN GENES ARE MORE RELATED TO THE DEVELOPMENT OF CCR, SUCH AS THE PROMITOTIC ONES. ON THE OTHER HAND, SOME NULL GENES MAY ALSO FAVOR THIS DISEASE, SUCH AS TUMOR SUPPRESSORS AND DETOXIFICATION GENES, WHICH, WHEN PRESENT, ARE PROTECTIVE. WHEN IT COMES TO FOOD, THE INFLUENCE OF FIBER-RICH FOODS IS NOTED, WHICH HAS SEEN FEWER CASES OF POLYPS AND CRC. OTHER IMPORTANT FINDINGS WERE THE GREATER PREDISPOSITION THAT MEN, PEOPLE OVER 50 YEARS OLD AND OBESE PEOPLE HAVE TO DEVELOP COLORECTAL ADENOMAS.
Referências
AL HARGAN, A., DAGHESTANI, M. H., HARRATH, A. H. Alterações nos nÃveis de expressão gênica APC, BECN1 e TP53 em células de câncer de cólon causadas por glutamato monossódico. Braz. J. Biol. v. 83, 2023.
ASADI, A., et al. Circulating ghrelin levels and susceptibility to colorectal cancer. Arquivos de Gastroenterologia, v. 58, n. 03, 2021.
BUAMDEN, S. Relación entre la disponibilidad alimentaria y la mortalidad por cáncer colorrectal en América. Salud Colect, n. 14, v. 3, 2018.
COSSIOLO, D. C., et al. Polymorphism of the cox-2 gene and susceptibility to colon and rectal cancer. ABCD. Arquivos Brasileiros de Cirurgia Digestiva, n. 2, v. 30, p. 114-117, 2017.
DE VRIES, E., et al. Population attributable fractions for colorectal cancer and red and processed meats in Colombia - a macro-simulation study. Colombia Médica, v. 48, n. 2, 2017.
FREITAS, B. A., et al. Are obesity and adenoma development associated as colorectal cancer precursors?. ABCD. Arquivos Brasileiros de Cirurgia Digestiva, n. 33, v. 1, 2020.
GUO, CG., et al. Aspirin Use and Risk of Colorectal Cancer Among Older Adults. JAMA Oncol, n. 3, v. 7, p. 428-435, 2021.
Instituto nacional de câncer José Alencar gomes da silva. Detecção precoce do câncer. Rio de Janeiro: INCA, 2021. DisponÃvel em: https://antigo.inca.gov.br/publicacoes/livros/deteccao-precoce-do-cancer. Acesso em: 01/11/2022.
JUNG, S. Y., ZHANG, Z. The effects of genetic variants related to insulin metabolism pathways and the interactions with lifestyles on colorectal cancer. Menopause, n. 26, v. 7, p. 771-780, 2019.
KHAN, A., et al. Associação de polimorfismo genético de glutationa S-transferase com suscetibilidade ao câncer colorretal em viciados em rapé (Naswar). Braz. J. Biol. v. 84, 2024.
KOPP, T. I.; VOGEL, U.; ANDERSEN, V. Associations between common polymorphisms in CYP2R1 and GC, Vitamin D intake and risk of colorectal cancer in a prospective case-cohort study in Danes. PloS one, n. 2, v. 15, 2020.
LOPES, E. C. F., DERIVI, S. C. N., MENDEZ, M. H. M. Importância da dieta na epidemiologia do câncer de cólon e reto. Rev. Saúde Pública, n. 18, v. 5, out 1984.
NOROLLAHI, S. E., et al. The fluctuation of APC gene in WNT signaling with adenine deletion of adenomatous polyposis coli, is associated in colorectal cancer. Journal of coloproctology, n. 40, v. 2, p. 135-142, 2019.
Organização Pan-Americana de Saúde (OPAS). Câncer. 2020. DisponÃvel em: https://www.paho.org/pt/topicos/cancer. Acesso em 24/10/2022.
PACHECO-PÉREZ, L. A., et al. Fatores ambientais e conscientização sobre o câncer colorretal em pessoas com risco familiar. Revista Latino-Americana de Enfermagem, v. 27, 2019.
PARTIDA, M., et al. LEPR polymorphism and haplotypes in Mexican patients with colorectal cancer. Biomédica, n. 1, v. 39, p. 205-211, 2019.
PEREZ, R. O., et al. Instalação e resultados preliminares de programa de rastreamento populacional de câncer colorretal em municÃpio brasileiro. ABCD. Arquivos Brasileiros de Cirurgia Digestiva, n. 21, v.1, 2008.
PICANÇO-JÚNIOR, O. M., et al. Presença do PapilomavÃrus Humano tipo 16 e expressão gênica da proteÃna P16 e oncoproteÃna E7 no carcinoma colorretal. ABCD. Arquivos Brasileiros de Cirurgia Digestiva, n. 34, v. 4, 2021.
ROMERO, C. E. M.; ZANESCO, A. O papel dos hormônios leptina e grelina na gênese da obesidade. Revista de Nutrição, v. 19, n. 1, 2006.
SILVA, A. R. B. M., et al. Polipose múltipla familiar: análise de 44 casos tratados no Hospital das ClÃnicas da FMRP-USP. Rev. Bras. Colo-proctol., n. 27, v. 3, set 2007.
SO, W. K. W., et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients, n. 2 v. 13, p. 526, 2021.
ZHANG, K., et al. Fermented dairy foods intake and risk of cancer. Int J Cancer, n. 144, v. 9, p. 2099–2108, 2019.
ZINATIZADEH, N., et al. Potential preventive effect of lactobacillus acidophilus and lactobacillus plantarum in patients with polyps or colorectal cancer. Arquivos de Gastroenterologia, n. 4, v. 55, p. 407-411, 2018.
