• Ana Laura Ferreira Rios UniEVANGÉLICA
  • Fernanda de Souza dos Santos Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Beatriz Araújo Costa Simões Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Tawane Tavares Silva Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Maria Luiza Silveira Lopes Nico Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Joelington Dias Batista Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Ludimila Dias Silva Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Rúbia Mariano da Silva Universidade Evangélica de Goiás - UniEVANGÉLICA


osteoarthritis, knee, elderly, PRP, hyaluronic acid, corticosteroids


This integrative literature review aims to evaluate the impacts of platelet-rich plasma (PRP) treatment in the treatment of knee osteoarthritis in the elderly, since it has been gaining more and more space in the medical field since its development. The main purpose of this study is to elucidate the impacts of platelet rich plasma (PRP) treatment in the treatment of knee osteoarthritis in the elderly.  This paper has been divided into five parts. In the introduction there is a brief clarification of two key concepts of the research – osteoarthritis (OA) and platelet rich plasma. In the methodology, all the search criteria and strategies used to obtain the articles used in the research are covered: PICO strategy, determination of a guiding question and inclusion and exclusion criteria. In the results, from 5 tables, divided according to the categories determined for grouping the articles found, a presentation of the main data addressed in each document was made. In the discussion, an analysis of the data found is presented, and it was noted that PRP constitutes a considerable means of treatment for the symptoms of knee osteoarthritis in the elderly when compared to other methods, but it still presents difficulties for its efficient establishment in the medical field, such as the lack of standardization in the composition, amount, and number of doses to be applied to each patient. Therefore, in conclusion, it was evident that the proposed objective was completed.


ARLIANI, Gustavo Gonçalves et al. Infiltração intraarticular de plasma rico em plaquetas versus ácido hialurônico em pacientes com osteoartrose primária do joelho: Ensaio clínico randomizado com resultados preliminares. Revista Brasileira de Ortopedia, v. 57, p. 402-408, 2022.

SU, Ke et al. Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis. Clinical Rheumatology, v. 37, n. 5, p. 1341-1350, 2018.

SUN, Shu-Fen et al. Comparing efficacy of intraarticular single crosslinked Hyaluronan (HYAJOINT Plus) and platelet-rich plasma (PRP) versus PRP alone for treating knee osteoarthritis. Scientific Reports, v. 11, n. 1, p. 1-10, 2021.

MALAHIAS, Michael-Alexander et al. Platelet-rich plasma versus corticosteroid intra-articular injections for the treatment of trapeziometacarpal arthritis: a prospective randomized controlled clinical trial. Cartilage, v. 12, n. 1, p. 51-61, 2021.

SUCUOĞLU, Hamza; ÜSTÜNSOY, Seyfettin. The short-term effect of PRP on chronic pain in knee osteoarthritis. The Journal of the Turkish Society of Algology, 2019.

O’DONNELL, Christian et al. Platelet‐rich plasma (PRP) from older males with knee osteoarthritis depresses chondrocyte metabolism and upregulates inflammation. Journal of Orthopaedic Research®, v. 37, n. 8, p. 1760-1770, 2019.

BOFFA, Angelo et al. Minimal clinically important difference and patient acceptable symptom state in patients with knee osteoarthritis treated with PRP injection. Orthopaedic Journal of Sports Medicine, v. 9, n. 10, p. 23259671211026242, 2021.

ALESSIO-MAZZOLA, Mattia et al. Clinical outcome and risk factor predictive for failure of autologous PRP injections for low-to-moderate knee osteoarthritis. Journal of Orthopaedic Surgery, v. 29, n. 2, p. 23094990211021922, 2021.

EYMARD, Florent; CHEVALIER, Xavier. Pharmacological treatments of knee osteoarthritis. La Revue du Praticien, v. 69, n. 5, p. 515-519, 2019

GHAI, Babita et al. Efetividade do plasma rico em plaquetas no tratamento da dor em osteoartrite de joelho: estudo comparativo randômico e duplo-cego. Revista Brasileira de Anestesiologia, v. 69, p. 439-447, 2019.

BANSAL, Himanshu et al. Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy. Scientific reports, v. 11, n. 1, p. 1-10, 2021.

RAHIMZADEH, Poupak et al. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clinical interventions in aging, v. 13, p. 73, 2018.

RASHEED, Nusrat et al. Role of platelet-rich plasma in early osteoarthritis of knee joint: Experience from a tertiary care center in Pakistan. Journal of Orthopaedic Surgery, v. 27, n. 2, p. 2309499019853953, 2019.

LOPA, Silvia et al. Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences. Knee surgery, sports traumatology, arthroscopy, v. 27, n. 6, p. 2003-2020, 2019.

DÓRIO, Murillo. Efficacy of platelet-rich plasma and plasma for symptomatic treatment of knee osteoarthritis: a double-blinded placebo-controlled randomized clinical trial. BMC Musculoskeletal Disorders. 2021. Disponível em: 06-7. Acesso em: 24 out. 2022.

TANIGUCHI, Yu. Intra-articular platelet-rich plasma (PRP) injections for treating knee pain associated with osteoarthritis of the knee in the Japanese population: a phase I and II clinical trial. Nagoya Journal of Medical Science. 2018. Disponível em: Acesso em: 24 out. 2022.

ZAHIR, Habib. In vitro responses to platelet-rich-plasma are associated with variable clinical outcomes in patients with knee osteoarthritis. Scientific Reports. 2021. Disponível em: Acesso em: 24 out. 2022. NUR KESIKTAS, Fatma .

Comparison of the short-term results of single-dose intra-articular peptide with hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized study. Clinical Rheumatology. 2020. Disponível em: Acesso em: 24 out. 2022. FREIRE, Marianna.

Efeito comparativo entre a infiltração de plasma rico em plaquetas e o uso de corticosteroides no tratamento de osteoatrite do joelho: estudo clínico prospectivo e randomizado. Revista Brasileira de Ortopedia. 2020. Disponível em: lasma-rico-em-plaquetas-e-o-uso-de-corticosteroides-no-tratamento-de-osteoartritedo-joelho--estudo-clinico#:~:text=CONCLUS%C3%83O%20Embora%20ambas%20 as%20terapias,as%20terapias%20aos%20180%20dias. Acesso em: 24 out. 2022.

ELKSNIŅŠ-FINOGEJEVS, Andrejs; VIDAL, Luis; PEREDISTIJS, Andrejs. Intra-articular platelet-rich plasma vs corticosteroids in the treatment of moderate knee osteoarthritis: a single-center prospective randomized controlled study with a 1-year follow up. Journal of Orthopaedic Surgery and Research, v. 15, n. 1, p. 1-10, 2020.

KORPERSHOEK, Jasmijn V. et al. Intra-articular injection with Autologous Conditioned Plasma does not lead to a clinically relevant improvement of knee osteoarthritis: a prospective case series of 140 patients with 1-year follow-up. Acta Orthopaedica, v. 91, n. 6, p. 743-749, 2020.

SARAF, Amit et al. Serial Platelet-Rich Plasma Intra-articular Injections in Kellgren and Lawrence Grade IV Knee Joint Osteoarthritis: A Prospective Blinded Placebo-Controlled Interventional Study. Indian Journal of Orthopaedics, v. 56, n. 10, p. 1722-1728, 2022.

HAN, Seung-Beom; SEO, In-Wook; SHIN, Young-Soo. Intra-articular injections of hyaluronic acid or steroids associated with better outcomes than platelet-rich plasma, adipose mesenchymal stromal cells, or placebo in knee osteoarthritis: A network meta-analysis. Arthroscopy: The Journal of Arthroscopic & Related Surgery, v. 37, n. 1, p. 292-306, 2021.