• Camila Machado Rizzo UniEvangélica
  • Natália Dias de Melo Alvares UniEvangélica
  • Vitória Reis Torres UniEvangélica
  • Lara Di Almeida Melo UniEvangélica
  • Vitor Costa Gomide UniEvangélica
  • Guilherme Coelho de Azevedo UniEvangélica


Myasthenia Gravis, anti-musk, pregnancy


Myasthenia gravis is a disease that generates strength loss in certain muscle groups, usually caused by the transmission failure of the acetylcholine receptor (ACRH) in the synaptic slit of the neuromuscular junction. In the case report, the patient, unlike the usual Myasthenia Gravis patients, has the Anti-Musk type, that had its major manifestation in her second pregnancy. She presented the first symptoms even before any of her pregnancies, but they passed in a few days, which is why she did not seek help in 2018. It evolved during her pregnancy in 2021, where she had difficulty performing the vomiting reflex, she also had speech disorders and difficulty swallowing. Even after the diagnosis, in 2021, during a miastenic crisis she was hospitalized for poor nutrition and to recieve immunoglobulin. The difficulty of the the diagnosis and health care concerning myasthenia gravis was confirmed during her pregnancy, because child bearing is a period marked by many endocrine variations and immunological activity. This report contributes to a limited number of women who have a normal pregnancy, but who also suffer from Myasthenia Gravis and its particularities.


CASTRO, Diego. Especialista Em Miastenia | Miastenia Gravis. 30 Mar. 2020, Acesso em 16 out. de 2022.

FERRAZ, Fernanda. Miastenia Gravis - O que é, quais os sintomas e como tratar. Revista Anchieta, . Hospital Anchieta, Taguatinga.Disponível em: .Acesso em: 15 de out. de 2022.

FERREIRA, L.T.; DIAS-TOSTA, E. Autoanticorpos na miastenia grave adquirida autoimune. Brasília Médica, v.52, n.2, p.53-65, 2015.

SANDERS, D.B., et al. International consensus guidance for management of myasthenia gravis: Executive summary. American Academy of Neurology, v.87, n.4, p.419-425, 2016.

YAMASHITA, R., et al. Anti-MuSK Positive Myasthenia Gravis with Anti-Lrp4 and Anti-titin Antibodies. Internal Medicine, v.60, n.1, p.137-140, 2021.

PAREDES, K. A., et al. Myasthenia gravis and pregnancy: impact and approach. Revista de Neurologia, v.75, n.5, p.117-122, 2022.

AYRES, Annelise, et al. Cognitive performance in patients with Myasthenia Gravis: an association with glucocorticosteroid use and depression. Dementia e Neuropsychologia, v.14, n.3, 2020.

RIVNER, Michael. H., et al. MuSK and Myasthenia Gravis due to other Antibodies. Neurologic clinics, v.36, n.2, p.293-310, 2018.

BRASIL. Ministério da Saúde. Portaria SAS/MS n° 229, de 10 de maio de 2010. Brasília, 2010.