THEORETICAL ANALYSIS OF THE EFFECTS OF COUNTERIONS ON THE SUPRAMOLECULAR ARRANGEMENT OF SULFAMETHOXAZOLE

Autores

  • José Luís Rodrigues Martins Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Álice Cristina Borges Morais Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Luiz Eduardo Krüger Dias Universidade Evangélica de Goiás - UniEVANGÉLICA
  • Hamilton Barbosa Napolitano Universidade Evangélica de Goiás - UniEVANGÉLICA

Palavras-chave:

supramolecular, theoretical analysis, sulfamethoxazole

Resumo

Sulfamethoxazole (SMZ) is a sulfonamide that acts by competitively inhibiting the formation of folate from p-aminobenzoic acid (PABA). In a drug development process, salt formation is a strategy to modulate its pharmacokinetic and physicochemical properties, such as: aqueous solubility, dissolution, purity, stability and toxicity. Among the Active Pharmaceutical Ingredients marketed in salt form, sulfamethoxazole belongs to the class of sulfonamides widely used in the treatment of urinary tract infections (PROHOTSKY; ZHAO, 2012). Sulfamethoxazole has low bioavailability, low permeability and low solubility, in addition to presenting low absorption by the intestinal mucosa and great variability is expected (ALSUBAIE et al., 2018). In this sense, a pharmaceutical strategy to overcome these challenges is to promote its formulation in the form of salt.

Referências

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Publicado

2022-11-30

Edição

Seção

ICEX_CIPEEX